A 2026 Nature Aging paper identifies a distinct p21+TREM2+ senescent macrophage state driving liver disease and chronic inflammation, with implications for senolytics and longevity
A Nature Aging study shows how LINE-1 retrotransposons trigger inflammation and cardiac aging through cGAS-STING signaling. Mechanisms, limits, and longevity implications.
GrimAge and iAge track real world function across adulthood, linking biological age to VO2max and mobility, and clarifying how inflammation drives decline.
Telomere attrition—gradual loss of chromosome caps—links to heart disease, immune decline, and frailty. Explore new data, lifestyle levers, and emerging therapies.