Longevityreview

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

Changing the lipid mix inside lysosomes reduced senescence in mouse kidney cells.

October 21, 2026

Biotechnology·Diet·Health·Science

Seragon Publishes Data on Longevity Drug SRN-901, Showing Record-Breaking Lifespan Extension in Mice

October 21, 2026

Biotechnology·Health·Products & Supplements·Science·Technology

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

October 16, 2026

Biotechnology·Science

Blue wireframe figure raises a capsule to their mouth as a golden glow radiates from the kidney area, symbolizing senolytic rejuvenation.

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

Tyler Kim

High-resolution scientific illustration of a central cluster of human cells exposed to two contrasting systemic environments. The left side shows a calm, blue, low-noise signaling field with sparse particles, where the cells appear uniform and stable. The right side shows a denser, warm-toned red/orange signaling field with more complex, dynamic particles, where the same cells appear slightly irregular and stressed. The image emphasizes how systemic signaling environments can influence cellular state without visible tissue damage.

Old Blood, Fast Aging: How a Human Organ-Chip Reveals the Biology of Systemic Aging

Sarah Smith

A photorealistic illustration of a lipid bilayer cell membrane undergoing oxidative damage, showing an intact, orderly membrane on the left transitioning into a disrupted region on the right where lipid chains are fragmented and breaking apart, with glowing orange-red oxidative reactions and nearby iron ions (Fe²⁺) catalyzing the damage.

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Ryan Nguyen

Diet

Biotechnology·Diet·Health·Science

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

October 21, 2026

Changing the lipid mix inside lysosomes reduced senescence in mouse kidney cells.

Biotechnology·Diet·Health·Products & Supplements·Science

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

April 24, 2026

A new Cell Metabolism study reveals ferro-aging, linking iron, lipid peroxidation, and cellular senescence, with surprising primate data on vitamin C.

A side-by-side scene showing hands typing on a modern laptop on the left and hands using a vintage typewriter on the right, set against a warm, glowing yellow background, symbolizing the contrast between old and new approaches.

Biotechnology·Diet·Science·Technology

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

March 21, 2026

Longevity science is shifting from NAD+ supplements to precision anti-aging therapies. Here’s what the data actually shows and what comes next.

A curated still life of polyphenol-rich foods arranged against a serene turquoise backdrop. A crisp red-striped apple rests in the foreground, while squares of dark chocolate perch on minimalist pale-blue blocks beside hazelnuts, loose green tea leaves, and a handwritten “Polyphenols” label. Behind them, clusters of green grapes, ruby strawberries, a glossy purple onion, and a single white garlic bulb create a vibrant tableau of color and texture, evoking the natural abundance of plant-based compounds that shape human health and longevity.

Biotechnology·Diet·Health·Science·Technology

Polyphenols and Longevity, Reviewed!

December 1, 2025

Polyphenols reshape how we age, from senescent cells to brain health. Here’s what the latest science really says about food, supplements, and longevity.

Latest

Biotechnology·Diet·Health·Science

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

October 21, 2026

Changing the lipid mix inside lysosomes reduced senescence in mouse kidney cells.

Biotechnology·Health·Products & Supplements·Science·Technology

Seragon Publishes Data on Longevity Drug SRN-901, Showing Record-Breaking Lifespan Extension in Mice

October 21, 2026

SRN-901 extends lifespan 33% and reduces frailty by 70%, reshaping aging biology through coordinated, multi-pathway intervention.

Biotechnology·Science

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

October 16, 2026

A gene-splicing protein reduced frailty progression in aged mice, offering a new target for aging research.

Biotechnology·Health·Products & Supplements·Science

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

July 17, 2026

A long-term dasatinib-and-quercetin study in aged mice used proteomics and singlecell sequencing to show senolytic kidney rejuvenation, restoring Klotho, PPARα metabolism, and repair.

Biotechnology·Science·Technology

Old Blood, Fast Aging: How a Human Organ-Chip Reveals the Biology of Systemic Aging

April 29, 2026

A 2026 Nature Biomedical Engineering study shows how old human serum rapidly induces aging in organ-chip tissues, uncovering systemic drivers of aging and new

Biotechnology·Diet·Health·Products & Supplements·Science

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

April 24, 2026

A new Cell Metabolism study reveals ferro-aging, linking iron, lipid peroxidation, and cellular senescence, with surprising primate data on vitamin C.

A weary janitor kneels in a deteriorating, debris-filled room, meticulously polishing a small, perfectly clean patch of floor while cracked walls, leaking pipes, and scattered trash surround him, symbolizing obsessive focus amid widespread decay.

Biotechnology

Senescent Macrophages Aren’t What We Thought: A New Cell State Rewires Inflammaging

April 21, 2026

A 2026 Nature Aging paper identifies a distinct p21+TREM2+ senescent macrophage state driving liver disease and chronic inflammation, with implications for senolytics and longevity

Visualization of genomic activation and cardiac aging showing LINE-1 increase over time and potential reversal through intervention, highlighting mechanisms of heart disease and longevity therapeutics

Biotechnology·Science

LINE-1 and Cardiac Aging: When the Genome Stops Staying Quiet

April 15, 2026

A Nature Aging study shows how LINE-1 retrotransposons trigger inflammation and cardiac aging through cGAS-STING signaling. Mechanisms, limits, and longevity implications.

Close-up scientific illustration of a mitochondrion with intact cristae structure, representing cellular energy production and its role in aging, mitochondrial dysfunction, and longevity biology.

Biotechnology·Science

A Death Protein That Doesn’t Kill: The Hidden Driver of Stem Cell Aging

April 13, 2026

A new study reveals how MLKL damages mitochondria in stem cells without killing them, offering a new lens on aging and longevity biology.

A luminous network of glowing blue nodes rises like a futuristic constellation against a cosmic horizon, each pillar crowned with a symbol of life’s machinery—DNA strands, chromosomes, mitochondria, and molecular structures—interwoven by radiant strands of light. The connections cascade downward into a dense web, suggesting a living system in motion, where biology is not isolated but intricately linked. Set against a gradient sky that shifts from deep indigo to warm orange, the scene evokes both the precision of advanced science and the quiet vastness of space, portraying aging as a complex, interconnected system rather than a single failing pillar.

Health·Science·Technology

Is Aging a Systems Problem? Microbiome, Immunity, and the Limits of Anti-Aging Science

March 27, 2026

New longevity science points to microbiome–immune–metabolic networks. Here’s what’s real, what’s uncertain, and what you can do now.

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PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

Old Blood, Fast Aging: How a Human Organ-Chip Reveals the Biology of Systemic Aging

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Diet

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Polyphenols and Longevity, Reviewed!

Latest

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

Old Blood, Fast Aging: How a Human Organ-Chip Reveals the Biology of Systemic Aging

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Senescent Macrophages Aren’t What We Thought: A New Cell State Rewires Inflammaging

LINE-1 and Cardiac Aging: When the Genome Stops Staying Quiet

A Death Protein That Doesn’t Kill: The Hidden Driver of Stem Cell Aging

Is Aging a Systems Problem? Microbiome, Immunity, and the Limits of Anti-Aging Science

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PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

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