Longevityreview

A researcher examines cultured cells through a microscope in a biomedical laboratory.

Autophagy and Senescent Cells: Restoring the Immune Cleanup

Restoring a cellular recycling pathway helped immune cells clear senescent cells in mice.

October 28, 2026

Biotechnology·Science·Technology

A woman in midlife sits beside a sunlit kitchen window, holding a mug and looking toward the garden.

Menopause and Aging: Study Maps a Sharp Physiological Transition

October 23, 2026

Biotechnology·Health·Lifestyle·Science

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

October 21, 2026

Biotechnology·Diet·Health·Science

Seragon Publishes Data on Longevity Drug SRN-901, Showing Record-Breaking Lifespan Extension in Mice

Michael Lopez

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

Brandon Rodriguez

Blue wireframe figure raises a capsule to their mouth as a golden glow radiates from the kidney area, symbolizing senolytic rejuvenation.

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

Tyler Kim

Diet

Biotechnology·Diet·Health·Science

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

October 21, 2026

Changing the lipid mix inside lysosomes reduced senescence in mouse kidney cells.

A photorealistic illustration of a lipid bilayer cell membrane undergoing oxidative damage, showing an intact, orderly membrane on the left transitioning into a disrupted region on the right where lipid chains are fragmented and breaking apart, with glowing orange-red oxidative reactions and nearby iron ions (Fe²⁺) catalyzing the damage.

Biotechnology·Diet·Health·Products & Supplements·Science

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

April 24, 2026

A new Cell Metabolism study reveals ferro-aging, linking iron, lipid peroxidation, and cellular senescence, with surprising primate data on vitamin C.

A side-by-side scene showing hands typing on a modern laptop on the left and hands using a vintage typewriter on the right, set against a warm, glowing yellow background, symbolizing the contrast between old and new approaches.

Biotechnology·Diet·Science·Technology

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

March 21, 2026

Longevity science is shifting from NAD+ supplements to precision anti-aging therapies. Here’s what the data actually shows and what comes next.

A curated still life of polyphenol-rich foods arranged against a serene turquoise backdrop. A crisp red-striped apple rests in the foreground, while squares of dark chocolate perch on minimalist pale-blue blocks beside hazelnuts, loose green tea leaves, and a handwritten “Polyphenols” label. Behind them, clusters of green grapes, ruby strawberries, a glossy purple onion, and a single white garlic bulb create a vibrant tableau of color and texture, evoking the natural abundance of plant-based compounds that shape human health and longevity.

Biotechnology·Diet·Health·Science·Technology

Polyphenols and Longevity, Reviewed!

December 1, 2025

Polyphenols reshape how we age, from senescent cells to brain health. Here’s what the latest science really says about food, supplements, and longevity.

Latest

An older man sits on a comfortable living room sofa, gently focused as he practices an acoustic guitar, his posture relaxed but intent. Soft daylight fills the room, and the warm wood of the guitar contrasts with the quiet calm of the space. His expression shows both concentration and joy, capturing the beauty of learning something new later in life — the quiet, meaningful effort that keeps the mind alive and the spirit engaged.

Health·Lifestyle·Science

What “Difficult Joy” Means (and why it matters for aging)

November 5, 2025

Discover how challenging, joyful learning strengthens the brain, builds resilience, and supports healthy aging through neuroplasticity and purposeful effort.

A researcher wearing white medical gloves holds a single capsule filled with multicolored microbeads, suspended against a soft-focus background of intertwining DNA double helices. The image symbolizes the fusion of genetics and medicine—precision therapies tailored to the individual—highlighting the promise of pharmacogenomics in shaping personalized, age-responsive treatments.

Biotechnology·Health·Lifestyle·Products & Supplements·Science

Longer, Better Lives through Pharmacogenomics: How Your Genes, Age, and Medicines Interact

November 3, 2025

How genes and biological age shape drug response, and how pharmacogenomics improves safety and effectiveness for older adults.

Biotechnology·Science·Technology

Biological Age Clocks are Maturing, But Can They Actually Tell Us Who Will Stay Strong?

October 30, 2025

GrimAge and iAge track real world function across adulthood, linking biological age to VO2max and mobility, and clarifying how inflammation drives decline.

A woman sits cross-legged on a mountain ledge at sunrise, hands resting in quiet meditation. Below her, a sea of clouds drifts through shadowed valleys, while the horizon glows with golden light. The image captures a moment of stillness and balance, symbolizing alignment between body, mind, and the natural rhythm of the day.

Diet·Health·Lifestyle·Science

Why “information timing” matters for longevity

October 28, 2025

Limiting late-night digital input may reduce stress, preserve circadian alignment, and slow aging—an attention diet for your longevity.

An open spiral notebook rests on a wooden surface, its ruled page filled with the bold red word “Metformin,” underlined for emphasis. A stethoscope, partly visible at the bottom edge, frames the scene and connects the handwritten note to medicine and health. The contrast of red ink against the lined paper suggests urgency and importance, while the rustic grain of the desk background gives the composition a grounded, tactile quality.

Biotechnology·Health·Science·Technology

Metformin and the Long Game: what a 60-year-old diabetes drug can teach us about slowing aging

October 24, 2025

Can metformin slow aging? Explore evidence from animals, humans, and primates on its impact on longevity, metabolism, and cognition.

Two hands form a circle against a blurred green landscape, framing a translucent set of recycling arrows that symbolize renewal and continuous cycles of life. Subtle glowing hexagons with icons for health, sustainability, and science float across the foreground, blending natural imagery with futuristic design to evoke the concept of cellular recycling and longevity.

Biotechnology·Health·Lifestyle·Products & Supplements·Science·Technology

Autophagy Shapes Aging: The City That Cleans Itself

October 22, 2025

Autophagy is the cell’s cleanup crew—declining with age but targetable by fasting, exercise, and new therapies to extend healthspan.

A gloved hand steadies a clear petri dish while a pipette delivers a single droplet of liquid into its center, capturing the precision and delicacy of laboratory stem cell research.

Biotechnology·Health·Science·Technology

Stem Cells For Longevity: What The Data Actually Says In 2025

October 16, 2025

A quick map of the landscape “Stem cell injections” cover several very different things in humans: Below I break down where there is persuasive

A contemplative older woman sits at her desk, laptop open, glasses in hand, as an hourglass steadily drains on the table before her—a quiet metaphor for time, aging, and the rhythms that govern life.

Health·Lifestyle·Science·Technology

Chronotherapy, aging, and the body’s master timetable

October 14, 2025

Chronotherapy for healthy aging: how timing sleep, light, meals, and meds can help—what’s proven, what’s hype—using current human evidence.

A double helix of DNA unfurls across the canvas in a splash of vivid color, each twisting strand painted in gradients of orange, green, blue, and violet. The structure appears alive, with pigments bursting outward like fragments of energy scattering into the air, evoking both the beauty and fragility of life’s code. The edges fade into soft washes of gray and teal, framing the central spiral as if suspended between order and chaos.

Biotechnology·Health·Science

Genomic Instability: When the Instruction Manual Frays

October 8, 2025

How DNA damage, telomeres, mtDNA, and immune sensing drive aging, and which levers may slow the cascade from genome errors to tissue decline.

Close-up of an elderly hand clasped over the other, its weathered skin carrying a constellation of dark age spots across the knuckles and wrist. The fine lines and mottled pigment tell a quiet story of time, sun, and cellular change, a living canvas where lipofuscin’s presence makes itself visible as speckled marks of aging.

Biotechnology·Products & Supplements·Science·Technology

Lipofuscin and Aging, Reviewed!

October 6, 2025

Lipofuscin is the cell’s stubborn waste. See how it drives aging through lysosomal failure, oxidative stress, and ferroptosis, and what science is doing about

Previous 1 2 3 4 5 … 21 Next

Autophagy and Senescent Cells: Restoring the Immune Cleanup

Menopause and Aging: Study Maps a Sharp Physiological Transition

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

SRSF1 and Aging: A Gene-Splicing Target Shows Promise in Mice

Senolytic Kidney Rejuvenation: Eight Months of Dasatinib + Quercetin

Diet

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Polyphenols and Longevity, Reviewed!

Latest

What “Difficult Joy” Means (and why it matters for aging)

Longer, Better Lives through Pharmacogenomics: How Your Genes, Age, and Medicines Interact

Biological Age Clocks are Maturing, But Can They Actually Tell Us Who Will Stay Strong?

Metformin and the Long Game: what a 60-year-old diabetes drug can teach us about slowing aging

Autophagy Shapes Aging: The City That Cleans Itself

Stem Cells For Longevity: What The Data Actually Says In 2025

Chronotherapy, aging, and the body’s master timetable

Genomic Instability: When the Instruction Manual Frays

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Brandon Rodriguez

Emily Wilson

Christopher Martinez

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Autophagy and Senescent Cells: Restoring the Immune Cleanup

Menopause and Aging: Study Maps a Sharp Physiological Transition

PLA2G15 and Kidney Aging: Why Lysosomal Lipid Composition Matters

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