Longevityreview

A photorealistic illustration of a lipid bilayer cell membrane undergoing oxidative damage, showing an intact, orderly membrane on the left transitioning into a disrupted region on the right where lipid chains are fragmented and breaking apart, with glowing orange-red oxidative reactions and nearby iron ions (Fe²⁺) catalyzing the damage.

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

A new Cell Metabolism study reveals ferro-aging, linking iron, lipid peroxidation, and cellular senescence, with surprising primate data on vitamin C.

April 24, 2026

Biotechnology·Diet·Health·Products & Supplements·Science

Seragon Publishes Data on Longevity Drug SRN-901, Showing Record-Breaking Lifespan Extension in Mice

April 23, 2026

Biotechnology·Health·Products & Supplements·Science·Technology

A weary janitor kneels in a deteriorating, debris-filled room, meticulously polishing a small, perfectly clean patch of floor while cracked walls, leaking pipes, and scattered trash surround him, symbolizing obsessive focus amid widespread decay.

Senescent Macrophages Aren’t What We Thought: A New Cell State Rewires Inflammaging

April 21, 2026

Biotechnology

Visualization of genomic activation and cardiac aging showing LINE-1 increase over time and potential reversal through intervention, highlighting mechanisms of heart disease and longevity therapeutics

LINE-1 and Cardiac Aging: When the Genome Stops Staying Quiet

Sarah Smith

Close-up scientific illustration of a mitochondrion with intact cristae structure, representing cellular energy production and its role in aging, mitochondrial dysfunction, and longevity biology.

A Death Protein That Doesn’t Kill: The Hidden Driver of Stem Cell Aging

Ryan Nguyen

A luminous network of glowing blue nodes rises like a futuristic constellation against a cosmic horizon, each pillar crowned with a symbol of life’s machinery—DNA strands, chromosomes, mitochondria, and molecular structures—interwoven by radiant strands of light. The connections cascade downward into a dense web, suggesting a living system in motion, where biology is not isolated but intricately linked. Set against a gradient sky that shifts from deep indigo to warm orange, the scene evokes both the precision of advanced science and the quiet vastness of space, portraying aging as a complex, interconnected system rather than a single failing pillar.

Is Aging a Systems Problem? Microbiome, Immunity, and the Limits of Anti-Aging Science

Christopher Martinez

Diet

Biotechnology·Diet·Health·Products & Supplements·Science

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

April 24, 2026

A new Cell Metabolism study reveals ferro-aging, linking iron, lipid peroxidation, and cellular senescence, with surprising primate data on vitamin C.

A side-by-side scene showing hands typing on a modern laptop on the left and hands using a vintage typewriter on the right, set against a warm, glowing yellow background, symbolizing the contrast between old and new approaches.

Biotechnology·Diet·Science·Technology

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

March 21, 2026

Longevity science is shifting from NAD+ supplements to precision anti-aging therapies. Here’s what the data actually shows and what comes next.

A curated still life of polyphenol-rich foods arranged against a serene turquoise backdrop. A crisp red-striped apple rests in the foreground, while squares of dark chocolate perch on minimalist pale-blue blocks beside hazelnuts, loose green tea leaves, and a handwritten “Polyphenols” label. Behind them, clusters of green grapes, ruby strawberries, a glossy purple onion, and a single white garlic bulb create a vibrant tableau of color and texture, evoking the natural abundance of plant-based compounds that shape human health and longevity.

Biotechnology·Diet·Health·Science·Technology

Polyphenols and Longevity, Reviewed!

December 1, 2025

Polyphenols reshape how we age, from senescent cells to brain health. Here’s what the latest science really says about food, supplements, and longevity.

A flat lay of sleep essentials rests against a deep blue background: two silky eye masks embroidered with closed golden lashes, one in midnight blue and the other in soft blush; a vintage mint-green alarm clock frozen at an early hour; scattered white tablets and a teabag suggesting nighttime rituals; delicate white feathers drifting like fragments of dreams; and small yellow stars placed playfully around the scene. The composition evokes the quiet architecture of restful sleep and the circadian cues that guide the body’s nightly restoration.

Diet·Health·Lifestyle·Science

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

November 25, 2025

How men and women age differently through the lens of circadian rhythms—exploring sleep, hormones, metabolism, and longevity through the science of our internal clocks.

Latest

A gloved hand steadies a clear petri dish while a pipette delivers a single droplet of liquid into its center, capturing the precision and delicacy of laboratory stem cell research.

Biotechnology·Health·Science·Technology

Stem Cells For Longevity: What The Data Actually Says In 2025

October 16, 2025

A quick map of the landscape “Stem cell injections” cover several very different things in humans: Below I break down where there is persuasive

A contemplative older woman sits at her desk, laptop open, glasses in hand, as an hourglass steadily drains on the table before her—a quiet metaphor for time, aging, and the rhythms that govern life.

Health·Lifestyle·Science·Technology

Chronotherapy, aging, and the body’s master timetable

October 14, 2025

Chronotherapy for healthy aging: how timing sleep, light, meals, and meds can help—what’s proven, what’s hype—using current human evidence.

A double helix of DNA unfurls across the canvas in a splash of vivid color, each twisting strand painted in gradients of orange, green, blue, and violet. The structure appears alive, with pigments bursting outward like fragments of energy scattering into the air, evoking both the beauty and fragility of life’s code. The edges fade into soft washes of gray and teal, framing the central spiral as if suspended between order and chaos.

Biotechnology·Health·Science

Genomic Instability: When the Instruction Manual Frays

October 8, 2025

How DNA damage, telomeres, mtDNA, and immune sensing drive aging, and which levers may slow the cascade from genome errors to tissue decline.

Close-up of an elderly hand clasped over the other, its weathered skin carrying a constellation of dark age spots across the knuckles and wrist. The fine lines and mottled pigment tell a quiet story of time, sun, and cellular change, a living canvas where lipofuscin’s presence makes itself visible as speckled marks of aging.

Biotechnology·Products & Supplements·Science·Technology

Lipofuscin and Aging, Reviewed!

October 6, 2025

Lipofuscin is the cell’s stubborn waste. See how it drives aging through lysosomal failure, oxidative stress, and ferroptosis, and what science is doing about

Four women stand shoulder to shoulder beneath a wide blue sky, laughter softening their faces. Their arms rest easily around each other, denim and bright colors mingling, the warmth of friendship and resilience shining through their smiles. The image evokes the vitality and joy of healthy aging.

Biotechnology·Diet·Health·Lifestyle·Politics·Science

Celebrating the International Day of Older Persons

October 1, 2025

Your practical guide to longevity and being celebrated one day.

An image of two skeletons shaking hands and conversing in front of a black background. Above their skeleton skulls, a spooky, haunting font with sharp lines and jagged edges reads "The Bones Are Talking... Is Your Lifespan Listening?"

Biotechnology·Health·Science

The Bones Are Talking. Is Your Lifespan Listening?

October 1, 2025

Bones do more than support—they secrete hormones like osteocalcin and Klotho that regulate aging, metabolism, immunity, and longevity.

An image illustrating some of the potential benefits that sirtuins provide. In the image, these include lipid metabolism in adipose tissue, neuroprotection, glucose and lipid homeostasis in the liver, repair and function in the muscle, and regulation of insulin secretion in the pancreas.

Biotechnology·Health·Products & Supplements·Science

Enzymes and Longevity, Reviewed!

September 29, 2025

Discover how aging enzymes—from sirtuins to ELOVL2 and methylation markers—shape longevity and what new research reveals for boosting healthspan.

An image of a questionaire with a single question, asking "Progeria: Do you know about it? There are two boxes for "Yes" and "No" with a pen hovering over the "No" box.

Biotechnology·Health·Science

Progeria, Progerin, and the Playbook of Human Aging

September 25, 2025

Learn about Progeria, what it is, why longevity researchers are interested, and how it impacts aging.

Health·Products & Supplements

Creatine: Enhancing Athletic Prowess and Cognitive Function

September 22, 2025

Creatine monohydrate boosts athletic performance and muscle mass, supports brain health, and is generally safe when taken at recommended doses.

Diet·Health

A Deep Dive into Dietary Fiber and Disease Prevention

September 18, 2025

Dietary fiber helps prevent chronic diseases like heart disease, type 2 diabetes, and chronic kidney disease. Increase fiber with whole grains, fruits, and vegetables.

Previous 1 2 3 4 5 … 20 Next

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Senescent Macrophages Aren’t What We Thought: A New Cell State Rewires Inflammaging

LINE-1 and Cardiac Aging: When the Genome Stops Staying Quiet

A Death Protein That Doesn’t Kill: The Hidden Driver of Stem Cell Aging

Is Aging a Systems Problem? Microbiome, Immunity, and the Limits of Anti-Aging Science

Diet

Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Polyphenols and Longevity, Reviewed!

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

Latest

Stem Cells For Longevity: What The Data Actually Says In 2025

Chronotherapy, aging, and the body’s master timetable

Genomic Instability: When the Instruction Manual Frays

Celebrating the International Day of Older Persons

The Bones Are Talking. Is Your Lifespan Listening?

Enzymes and Longevity, Reviewed!

Progeria, Progerin, and the Playbook of Human Aging

Creatine: Enhancing Athletic Prowess and Cognitive Function

A Deep Dive into Dietary Fiber and Disease Prevention

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Brandon Rodriguez

Emily Wilson

Christopher Martinez

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Ferro-Aging: Iron and Lipid Damage May Be Driving Aging at Its Core

Senescent Macrophages Aren’t What We Thought: A New Cell State Rewires Inflammaging

LINE-1 and Cardiac Aging: When the Genome Stops Staying Quiet

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