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mtDNA dysfunction

3D molecular illustration of an i-motif DNA structure, showcasing the unique intercalated four-stranded cytosine-rich formation distinct from the canonical double helix in the background. The i-motif, stabilized under acidic conditions, plays a dynamic role in gene regulation and adds complexity to genomic architecture, contributing to the accumulation of DNA damage with age.

New Structures for DNA Damage Discovered: Implications for Aging

How DNA damage, repair failure, and mutational buildup silently drive aging, disease, and cellular decline—down to the molecular level.

April 30, 2025

Biotechnology·Science·Technology

An image of a white, futuristic lab, with articulated robotic arms in the background.

Top 10 Up and Coming Longevity Topics

May 16, 2025

Read about the top curated up-and-coming longevity technologies!

Ethel Caterham, the world’s oldest living person in 2025 at age 115, smiles while celebrating her birthday at a care home in Surrey, England. Surrounded by pink and purple balloons, she embodies calm and independence—traits she credits for her longevity.

Secrets of Longevity from the World’s Oldest People

May 15, 2025

Learn the secrets of longevity from the world’s oldest people,

SRN-901

Seragon’s SRN-901: Breakthrough Aging Intervention Drug Achieves Dramatic Lifespan Extension in Preclinical Study

May 7, 2025

In a May 7, 2024 press release, Seragon Biosciences announced

3D illustration of mitochondria inside neural tissue, highlighting the intricate inner membrane structure (cristae) and electron transport chains. This visualization symbolizes mitochondrial function in energy production and its decline with age, a core topic in the article on how mitochondrial dysfunction contributes to aging and age-related disease.

Longevity Reviewed! How to Optimize Your Aging Mitochondria

May 2, 2025

Mitochondria decline with age, but science shows we can restore