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somatic mutation

3D molecular illustration of an i-motif DNA structure, showcasing the unique intercalated four-stranded cytosine-rich formation distinct from the canonical double helix in the background. The i-motif, stabilized under acidic conditions, plays a dynamic role in gene regulation and adds complexity to genomic architecture, contributing to the accumulation of DNA damage with age.

New Structures for DNA Damage Discovered: Implications for Aging

How DNA damage, repair failure, and mutational buildup silently drive aging, disease, and cellular decline—down to the molecular level.

April 30, 2025

Biotechnology·Science·Technology

An image of a fuel gauge with a cartoon person in the middle holding up a barbell with weights on it, signifying the fuel gauge of a person instead of a vehicle.

The Body’s Fuel Gauge: How Nutrient Sensing Shapes Human Aging

August 29, 2025

How the body’s fuel sensors—mTOR, IGF-1, AMPK, and sirtuins—shape aging,

A young man in a black and red jacket sits on a grassy hillside at sunset, gently holding the face of a golden Labrador retriever. The two face each other closely, sharing an intimate and peaceful moment, with the blurred city skyline and vivid orange-pink sky glowing in the background. The dog’s mouth is slightly open as if panting or smiling, while the man looks at him with affection, creating a scene of companionship and tranquility.

Do Dogs Help Us Age Better? Here’s What the Latest Science Actually Says.

August 26, 2025

Dog ownership can boost health and longevity—but also carries risks.

A young woman staring at her phone in the dark while laying on her side in bed. A harsh blue light is emitting from her phone, while a softer blue light is being emitted on the back wall behind her bed.

Blue light, sleep, and aging: what the strongest science actually says

August 19, 2025

Blue light shapes sleep and aging biology. Get bright days,

The image shows a close-up of a person’s fingers gently holding a glowing point of light. Above the light, a three-dimensional DNA double helix made of tiny, reflective particles rises upward against a smooth, dark blue background. The scene gives the impression of someone delicately holding or creating genetic material, symbolizing concepts like biotechnology, synthetic biology.

Synthetic Biology vs. Aging in the Quest for Human Longevity

August 14, 2025

Synthetic biology is rewiring aging with gene circuits, senolytics, and