sirt3

3D-rendered illustration of a human cell with a detailed cutaway view showing the nucleus, endoplasmic reticulum, and multiple mitochondria. One mitochondrion is magnified in an inset, glowing with bright particle effects to depict active energy production and signaling. The image represents mitochondrial function, cellular energy metabolism, and the role of mitochondria in aging and mitophagy, aligning with themes from the article on mitochondrial health and complex I modulation.

Mitophagy vs. Complex I Inhibitors: Which is Better?

Discover how mitophagy and Complex I inhibitors impact aging, inflammation, and tissue repair—and which path may best support healthy mitochondrial function.

July 21, 2025

Biotechnology·Health·Products & Supplements·Science

3D rendering of NMN-loaded extracellular vesicles (sEVs) interacting with a cell surface, representing the advanced anti-aging therapy discussed in the article.

NAD+ & SIRT3 Power: New NMN-EVs Reverse Skin Aging in Mice

Revolutionary NMN-packed stem cell vesicles (NMN-sEVs) show stunning results in reversing skin aging in mice by boosting NAD+ and cellular repair.

July 18, 2025

Biotechnology·Science·Technology

Two female scientists in lab coats analyze data on a computer in a modern laboratory, with a microscope and test tubes in the foreground. A male scientist works in the background.

SIRT3 Clinical Trial, Sirtuins, and Longevity: Are We on the Verge of a Breakthrough?

SIRT3, the mitochondrial regulator, holds promise for longevity. Discover how clinical trials aim to harness its power for healthspan extension.

February 25, 2025

Biotechnology·Health·Science·Technology

A contemplative older woman sits at her desk, laptop open, glasses in hand, as an hourglass steadily drains on the table before her—a quiet metaphor for time, aging, and the rhythms that govern life.

Chronotherapy, aging, and the body’s master timetable

October 14, 2025

Chronotherapy for healthy aging: how timing sleep, light, meals, and

A double helix of DNA unfurls across the canvas in a splash of vivid color, each twisting strand painted in gradients of orange, green, blue, and violet. The structure appears alive, with pigments bursting outward like fragments of energy scattering into the air, evoking both the beauty and fragility of life’s code. The edges fade into soft washes of gray and teal, framing the central spiral as if suspended between order and chaos.

Genomic Instability: When the Instruction Manual Frays

October 8, 2025

How DNA damage, telomeres, mtDNA, and immune sensing drive aging,

Close-up of an elderly hand clasped over the other, its weathered skin carrying a constellation of dark age spots across the knuckles and wrist. The fine lines and mottled pigment tell a quiet story of time, sun, and cellular change, a living canvas where lipofuscin’s presence makes itself visible as speckled marks of aging.

Lipofuscin and Aging, Reviewed!

October 6, 2025

Lipofuscin is the cell’s stubborn waste. See how it drives

Four women stand shoulder to shoulder beneath a wide blue sky, laughter softening their faces. Their arms rest easily around each other, denim and bright colors mingling, the warmth of friendship and resilience shining through their smiles. The image evokes the vitality and joy of healthy aging.

Celebrating the International Day of Older Persons

October 1, 2025

Your practical guide to longevity and being celebrated one day.

Mitophagy vs. Complex I Inhibitors: Which is Better?

NAD+ & SIRT3 Power: New NMN-EVs Reverse Skin Aging in Mice

SIRT3 Clinical Trial, Sirtuins, and Longevity: Are We on the Verge of a Breakthrough?

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Authors

Emily Wilson

Christopher Martinez

Brandon Rodriguez

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