Longevityreview

A side-by-side scene showing hands typing on a modern laptop on the left and hands using a vintage typewriter on the right, set against a warm, glowing yellow background, symbolizing the contrast between old and new approaches.

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Longevity science is shifting from NAD+ supplements to precision anti-aging therapies. Here’s what the data actually shows and what comes next.

March 21, 2026

Biotechnology·Diet·Science·Technology

Seragon’s SRN-901: Breakthrough Aging Intervention Drug Achieves Dramatic Lifespan Extension in Preclinical Study

March 20, 2026

Biotechnology·Health·Science·Technology

A curated still life of polyphenol-rich foods arranged against a serene turquoise backdrop. A crisp red-striped apple rests in the foreground, while squares of dark chocolate perch on minimalist pale-blue blocks beside hazelnuts, loose green tea leaves, and a handwritten “Polyphenols” label. Behind them, clusters of green grapes, ruby strawberries, a glossy purple onion, and a single white garlic bulb create a vibrant tableau of color and texture, evoking the natural abundance of plant-based compounds that shape human health and longevity.

Polyphenols and Longevity, Reviewed!

December 1, 2025

Biotechnology·Diet·Health·Science·Technology

A small circle of older friends gathers outdoors beneath a canopy of warm evening light, faces alive with laughter and recognition. Their hands rest gently on each other’s shoulders as if closing an invisible circuit of care. Behind them, the soft blur of trees and sky seems to echo their calm vitality—a quiet visual proof that belonging itself is a form of medicine. The scene radiates the essence of social embeddedness: the way human connection slows the passage of time and nourishes longevity more deeply than any supplement ever could.

The Longevity of “Us”: What Social Embedding Really Does to Human Aging

Brandon Rodriguez

A flat lay of sleep essentials rests against a deep blue background: two silky eye masks embroidered with closed golden lashes, one in midnight blue and the other in soft blush; a vintage mint-green alarm clock frozen at an early hour; scattered white tablets and a teabag suggesting nighttime rituals; delicate white feathers drifting like fragments of dreams; and small yellow stars placed playfully around the scene. The composition evokes the quiet architecture of restful sleep and the circadian cues that guide the body’s nightly restoration.

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

Tyler Kim

A bright red balloon ruptures midair, frozen in the instant its membrane gives way, sending a crystalline explosion of water outward against a clear blue sky. Droplets scatter in every direction like fractured glass, capturing the drama of a boundary pushed past its limit and the sudden release of what was once contained.

Lysosomal Permeability, Reviewed! New Contender in The Hallmarks of Aging

Sarah Smith

Diet

Biotechnology·Diet·Science·Technology

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

March 21, 2026

Longevity science is shifting from NAD+ supplements to precision anti-aging therapies. Here’s what the data actually shows and what comes next.

Biotechnology·Diet·Health·Science·Technology

Polyphenols and Longevity, Reviewed!

December 1, 2025

Polyphenols reshape how we age, from senescent cells to brain health. Here’s what the latest science really says about food, supplements, and longevity.

Diet·Health·Lifestyle·Science

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

November 25, 2025

How men and women age differently through the lens of circadian rhythms—exploring sleep, hormones, metabolism, and longevity through the science of our internal clocks.

A sleepless person sits upright in bed with hands gently pressed to their temples, eyes tired and face drawn with exhaustion. Soft cartoon sheep float across a deep blue night sky scattered with tiny stars, suggesting the familiar struggle of counting sheep that offers no relief. The scene conveys the quiet frustration and emotional weight of insomnia, capturing the intimate moment when the mind refuses to rest even as the world around grows still.

Biotechnology·Diet·Health·Lifestyle·Science

The Night Shift of Aging: Why Sleep Changes As We Get Older

November 17, 2025

How insomnia and sleep apnea shape aging, summarizing new evidence on mortality, cognition, frailty, and treatments that can bend the curve.

Latest

An image of a fuel gauge with a cartoon person in the middle holding up a barbell with weights on it, signifying the fuel gauge of a person instead of a vehicle.

Biotechnology·Health·Lifestyle·Products & Supplements·Science

The Body’s Fuel Gauge: How Nutrient Sensing Shapes Human Aging

August 29, 2025

How the body’s fuel sensors—mTOR, IGF-1, AMPK, and sirtuins—shape aging, and what human studies say about nutrient sensing, diet, exercise, drugs, and biomarkers that

A young man in a black and red jacket sits on a grassy hillside at sunset, gently holding the face of a golden Labrador retriever. The two face each other closely, sharing an intimate and peaceful moment, with the blurred city skyline and vivid orange-pink sky glowing in the background. The dog’s mouth is slightly open as if panting or smiling, while the man looks at him with affection, creating a scene of companionship and tranquility.

Health·Lifestyle·Science

Do Dogs Help Us Age Better? Here’s What the Latest Science Actually Says.

August 26, 2025

Dog ownership can boost health and longevity—but also carries risks. Here’s what the latest science says about aging with canine companions.

A young woman staring at her phone in the dark while laying on her side in bed. A harsh blue light is emitting from her phone, while a softer blue light is being emitted on the back wall behind her bed.

Health·Lifestyle·Science

Blue light, sleep, and aging: what the strongest science actually says

August 19, 2025

Blue light shapes sleep and aging biology. Get bright days, dim evenings, and dark nights to protect melatonin, metabolism, and long term health.

The image shows a close-up of a person’s fingers gently holding a glowing point of light. Above the light, a three-dimensional DNA double helix made of tiny, reflective particles rises upward against a smooth, dark blue background. The scene gives the impression of someone delicately holding or creating genetic material, symbolizing concepts like biotechnology, synthetic biology.

Biotechnology·Health·Science·Technology

Synthetic Biology vs. Aging in the Quest for Human Longevity

August 14, 2025

Synthetic biology is rewiring aging with gene circuits, senolytics, and reprogramming to boost healthspan while building in strict safety controls.

A young woman asleep in her bed, covered by a fluffy white comforter and soft white pillows. A soft purple hue lights the image with an overlay of the word "Melatonin" and the melatonin chemical structure.

Biotechnology·Health·Lifestyle·Science

Circadian Rhythms and Longevity: The Science of Aging on Time

August 12, 2025

How circadian rhythms influence human aging—from metabolism and sleep to menopause, TRE, rapamycin, mitochondria and molecular clocks.

A microscope's view of the bone's trabacular structures, artificially colored in teal and red accents.

Biotechnology·Health·Science

Bone Deep: How Your Skeleton Secretly Shapes Your Longevity

August 8, 2025

Your skeleton does more than support you—it may regulate aging. Discover how bone hormones like osteocalcin shape metabolism, memory, and lifespan.

A cartoon image of a man in a blue suit jacket, yellow tie, and navy pants with his tie flapping in the wind to his right, set on the backdrop of a blue sky with fluffy white clouds. His right arm is bent at the elbow upwards as if to raise something above his head. Hovering above his open hand is a sparkling clock, symbolizing time management. His left are is also bent upward at the elbow and his hand is making the motion of spinning a basketball with an outstretched finder. Hovering above his finger is a pie chart with a light bulb inside illustrating the idea of proper structured procrastination can be achieved while improving time management and efficiency.

Health·Lifestyle·Science

What Is Structured Procrastination?

August 7, 2025

Structured procrastination may influence aging. Discover how motivation, stress, and health habits shape your lifespan—and what science says about delaying wisely.

An image of a syringe targeting a cancer cell on an orange background. Two cancer cells are in the background about to be targeted by the new immunotherapy.

Biotechnology·Science·Technology

Senolytic Immune Cells Get a Facelift

August 5, 2025

Explore how senolytic CAR-T and CAR-NK therapies are reshaping aging by clearing senescent cells and restoring youthful function.

3D-rendered illustration of a human cell with a detailed cutaway view showing the nucleus, endoplasmic reticulum, and multiple mitochondria. One mitochondrion is magnified in an inset, glowing with bright particle effects to depict active energy production and signaling. The image represents mitochondrial function, cellular energy metabolism, and the role of mitochondria in aging and mitophagy, aligning with themes from the article on mitochondrial health and complex I modulation.

Biotechnology·Health·Products & Supplements·Science

Mitophagy vs. Complex I Inhibitors: Which is Better?

July 21, 2025

Discover how mitophagy and Complex I inhibitors impact aging, inflammation, and tissue repair—and which path may best support healthy mitochondrial function.

3D rendering of NMN-loaded extracellular vesicles (sEVs) interacting with a cell surface, representing the advanced anti-aging therapy discussed in the article.

Biotechnology·Science·Technology

NAD+ & SIRT3 Power: New NMN-EVs Reverse Skin Aging in Mice

July 18, 2025

Revolutionary NMN-packed stem cell vesicles (NMN-sEVs) show stunning results in reversing skin aging in mice by boosting NAD+ and cellular repair.

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Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Seragon’s SRN-901: Breakthrough Aging Intervention Drug Achieves Dramatic Lifespan Extension in Preclinical Study

Polyphenols and Longevity, Reviewed!

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

Lysosomal Permeability, Reviewed! New Contender in The Hallmarks of Aging

Diet

Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Polyphenols and Longevity, Reviewed!

Sex-Specific Differences in Circadian Rhythms and Aging, Reviewed!

The Night Shift of Aging: Why Sleep Changes As We Get Older

Latest

The Body’s Fuel Gauge: How Nutrient Sensing Shapes Human Aging

Do Dogs Help Us Age Better? Here’s What the Latest Science Actually Says.

Blue light, sleep, and aging: what the strongest science actually says

Synthetic Biology vs. Aging in the Quest for Human Longevity

Circadian Rhythms and Longevity: The Science of Aging on Time

Bone Deep: How Your Skeleton Secretly Shapes Your Longevity

What Is Structured Procrastination?

Senolytic Immune Cells Get a Facelift

Mitophagy vs. Complex I Inhibitors: Which is Better?

NAD+ & SIRT3 Power: New NMN-EVs Reverse Skin Aging in Mice

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Brandon Rodriguez

Emily Wilson

Christopher Martinez

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Longevity Science Is Moving Beyond NAD+—Toward Precision Anti-Aging Therapies

Seragon’s SRN-901: Breakthrough Aging Intervention Drug Achieves Dramatic Lifespan Extension in Preclinical Study

Polyphenols and Longevity, Reviewed!

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